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May 22, 2018: Life Technologies issued new U.S. patent [9,976,128]

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Life Technologies has been issued a new U.S. patent titled "Polymerase compositions, methods of making and using same" by the US Patent and Trademark Office.

ABSTRACT

The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase.

Appl. No.14/754,203

INDEX

SECTION 1 LIFE TECHNOLOGIES PROFILE

SECTION 2 LIFE TECHNOLOGIES PATENTS

SECTION 1 LIFE TECHNOLOGIES PROFILE

1.1 SUMMARY

Website: http://www.lifetechnologies.com/au/en/home.html

Industry: Heathcare

SECTION 2 LIFE TECHNOLOGIES PATENTS

2.1 Number of Patents Issued to Life Technologies (Past 12 Months)

There were a total of 138 patents issued to Life Technologies in the past 12 months. The highest number (17) were issued in April, 2018.

MonthsNo. of Patents Issued
May14
April17
March12
February9
January14
December8
November10
October11
September11
August15
July11
June6
Total (Past 12 Months)138

2.2 Patents issued by the US PTO and the EPO on same inventions

In the past 24 months the following 3 patents were issued by the USPTO and the European Patent Office (EPO) to Life Technologies.

TitleUS PTOEPO
Compositions, Methods, Systems And Kits For Target Nucleic Acid Enrichment9,957,552; 01 May, 2018EP3252174 (A1); 06 Dec, 2017
Fluid Mixing System With Drive Shaft Steady Support9,700,857; 11 Jul, 2017US9700857 (B1); 11 Jul, 2017
Lysis Buffers For Extracting Nucleic Acids9,447,409; 20 Sep, 2016EP3124596 (A1); 01 Feb, 2017

2.3 Previous 10 LIFE TECHNOLOGIES Patent titles:

Issue DateIssuing OfficePatent TitlePatent Number
May 15, 2018US PTOOligonucleotides and methods for the preparation of RNA libraries9,970,048
May 15, 2018US PTOApparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof9,968,903
May 15, 2018US PTOMethod and apparatus for identifying defects in a chemical sensor array9,970,984
May 8, 2018US PTOIntegrated sensor arrays for biological and chemical analysis9,964,515
May 8, 2018US PTOSelf-locking door and product dispensing enclosure having a self-locking door9,963,912
May 8, 2018US PTODevice and methods for quantifying analytes9,964,490
May 1, 2018US PTOCassette support base for electrophoresis gel castingD816,865
May 1, 2018US PTOChemically sensitive sensor with lightly doped drains9,960,253
May 1, 2018US PTOChemFET sensor including floating gate9,958,415
May 1, 2018US PTOApparatus for measuring analytes including chemical sensor array9,958,414

2.4 Previous 5 LIFE TECHNOLOGIES Patent abstracts:

May 15, 2018 Life Technologies issued new U.S. patent [9,970,048]

ABSTRACT

Disclosed are compositions and methods for the preparation of RNA libraries for sequencing, gene expression profiling, microarray and other uses and for simplification of the library preparation process. The disclosure provides blocking oligonucleotides which bind to byproduct nucleic acid molecules formed during the ligation of adapters to nucleic acid segments prior to sequencing and inhibit or block amplification of the byproduct nucleic acid molecules in subsequent amplification reactions. Methods for library preparation using blocking oligonucleotides are also provided.

May 15, 2018 Life Technologies issued new U.S. patent [9,968,903]

ABSTRACT

The invention features methods of making devices, or "platens", having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

May 15, 2018 Life Technologies issued new U.S. patent [9,970,984]

ABSTRACT

In one implementation, a method for operating an apparatus is described. The method includes applying a bias voltage to place a transistor of a reference sensor in a known state. The reference sensor is in an array of sensors that further includes a chemical sensor coupled to a reaction region for receiving at least one reactant. The method further includes acquiring an output signal from the reference sensor in response to the applied bias voltage. The method further includes determining a defect associated with the array if the output signal does not correspond to the known state.

May 8, 2018 Life Technologies issued new U.S. patent [9,964,515]

ABSTRACT

An apparatus comprising a chemical field effect transistor array in a circuit-supporting substrate is disclosed. The transistor array has disposed on its surface an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid. The transistor array has a pitch of 10 .mu.m or less and a sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region.

May 8, 2018 Life Technologies issued new U.S. patent [9,963,912]

ABSTRACT

Provided herein is an inventory management system for dispensing products from an enclosure, methods of securing products within the enclosure, use of the enclosure and for maintaining inventory. The inventory management system may include an enclosure having a self-locking door. The self locking door may include a door, a lock located on the door, a strike plate, wherein the strike plate controls the lock, and a sensor configured to detect the presence of a user and wherein the sensor controls the lock.

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